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Lower Bounds for Optimal Alignments of Binary Sequences

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 نشر من قبل Cynthia Vinzant
 تاريخ النشر 2011
  مجال البحث علم الأحياء
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 تأليف Cynthia Vinzant




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In parametric sequence alignment, optimal alignments of two sequences are computed as a function of the penalties for mismatches and spaces, producing many different optimal alignments. Here we give a 3/(2^{7/3}pi^{2/3})n^{2/3} +O(n^{1/3} log n) lower bound on the maximum number of distinct optimal alignment summaries of length-n binary sequences. This shows that the upper bound given by Gusfield et. al. is tight over all alphabets, thereby disproving the square root of n conjecture. Thus the maximum number of distinct optimal alignment summaries (i.e. vertices of the alignment polytope) over all pairs of length-n sequences is Theta(n^{2/3}).



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