C-odd asymmetry can be studied from an accurate measurement of the angular distribution due to the interference between the S- and P-waves in e+e- --> pi+ pi- at order alpha^3. The asymmetry is dominated by the pion rescattering diagram which is enhanced by the presence of the ln(s/m^2_e), and is quite large (10% at theta=30^0 and sqrt{s} < M_{f_2}) compared to alpha/pi=0.3%. This process can also be used for alternatively measuring the size of the rescattering term and the phase of the S-wave amplitude, but does not help to solve the present discrepancy between the hadronic spectral functions from e+e- and tau-decay data.