Using the notions of frame transform and of square integrable projective representation of a locally compact group $G$, we introduce a class of isometries (tight frame transforms) from the space of Hilbert-Schmidt operators in the carrier Hilbert space of the representation into the space of square integrable functions on the direct product group $Gtimes G$. These transforms have remarkable properties. In particular, their ranges are reproducing kernel Hilbert spaces endowed with a suitable star product which mimics, at the level of functions, the original product of operators. A phase space formulation of quantum mechanics relying on the frame transforms introduced in the present paper, and the link of these maps with both the Wigner transform and the wavelet transform are discussed.