A new Spectrophotometric Method for the Determination of Lisinopril in Bulk and Tablets after Derivatization with 4- Nitrobenzene Diazonium Tetra Fluoro Borate

A new colorimetric analytical method was developed for determination of Lisinopril in bulk and tablets . The method is depended on derivatization chemical reaction between Lisinopril and 4- nitrobenzene diazonium tetra fluoro borate in non aqueous medium to give color derivatives with max. absorption at 293.8 nm . The resulting color was measured spectrophotometrically . The absorbance concentration plots were recti linear over the range 5-50 μg /ml. The method applied for determination the Lisinopril in Tablet, The percentage recoveries was 98% ± 2.4. The results obtained were in accordance with those found using the HPLC standard method in Pharmacopoeia .